DFG: Priority Program “Ferroptosis: from Molecular Basics to Clinical Applications” (deadline: Oct 28, 2020)
Ferroptosis is a prevalent and disease-relevant form of cell death characterized by specific metabolic constraints and an iron-dependent accumulation of lipid hydroperoxides. Emerging evidence suggests that ferroptosis is an ancient form of cell death and an evolutionary conserved susceptibility to cell death caused by the incorporation of polyunsaturated fatty acids into cellular membranes. Notably, this complex cellular death pathway has been found to be dysfunctional in various pathological contexts. These findings have stimulated a growing need to understand the underlying genetic and metabolic determinants that regulate ferroptosis in order to provide new avenues for their modulation in a therapeutic context.
Therefore, applications addressing the following topics are explicitly discouraged:
- general topics in the fields of redox regulation, cell death mechanism and iron/thiol metabolism lacking a clear link to ferroptosis
- untargeted development of small molecules modulating ferroptosis
- solely methodology-driven projects, unless supported by a strong research hypothesis in the ferroptosis field
- purely exploratory projects addressing the sensitivity of cells/tissues towards ferroptosis
- analysis of collections of patient biopsies without any clear mechanistic question
Proposals must be written in English and submitted to the DFG by October 28, 2020 via elan, the DFG’s electronic proposal processing system.
For further information see www.dfg.de/foerderung/info_wissenschaft/info_wissenschaft_20_37/index.html