Information from GAUSS & GAUSS Career Service

DFG Priority Program “Spatial Genome Architecture in Development and Disease” (apply by 15 Feb 2022)

DruckThe DFG has an open call on one of their priority programsSpatial Genome Architecture in Development and Disease” with application to be submitted by 15 February 2022.

Genomic information is modified and regulated by a number of additional layers. One of these, the spatial folding of chromosomes, has been recently identified as a major factor for gene regulation. The  Priority Programme aims at dissecting the structure-to-function relationship of the genomes of higher metazoans at high spatio-temporal resolution in study systems relevant to genome integrity, development or disease.

In order to reach this goal all projects should include one or more of the following goals:

  • develop and apply novel technologies that can capture spatial chromatin conformation, also in conjunction with other genomic features, to resolve and track features of genomic architecture in the nucleus down to the single cell-level
  • functionally dissect the impact of 3D chromatin folding on gene expression or genome integrity in in vitro and in vivo model systems or human samples during development cell differentiation
  • causally connect 3D chromatin folding with disease pathology by integrating precision genome editing and patient data and/or disease models
  • develop and apply novel computational approaches that will allow us to integrate, visualise, and quantitatively model the end-effects and dynamics of spatial genome organisation

Proposals must be written in English and submitted to the DFG by 15 February 2022 via elan, the DFG’s electronic proposal processing system. For further information check out the specific webpage here.